Project Summary
The aim of our workl is to establish the basic conditions for DNA-based nano-biotechnology. The programme, which rests on biochemistry, advanced co-ordination chemistry, molecular spectroscopy, surface physics and theoretical chemistry comprises:

(1) The optimisation of topology and dynamics of surface-immobilised DNA hybrids using a novel spectroscopic approach applying electrochemical and spectroscopic techniques in parallel.

(2) The development of novel binding procedures of DNA to metal or semiconductor surfaces.

(3) Tailored modifications of DNA oligomers and assembly of complex DNA architectures as elements of biosensor devices.
(4) High-resolution mapping of the metal/DNA interface.
(5) The investigation of intra-hybrid charge transfer based on time-resolved optical spectroscopy. (6) The study of interfacial charge transfer using scanning tunnelling microscopy.

(7) An assessment of the mechanism of electron transport in DNA hybrids and across metal/DNA interfaces based on NMR structure and sophisticated molecular modelling simulations.

The strong impact expected from this joint effort rests on the combination of different synthetic approaches, the high level of structural resolution, time-resolved electron transport dynamics, topology and electrochemistry of surface-immobilised hybrids of DNA and its analogues, and single molecule imaging techniques as well as on quantum chemistry and molecular dynamics simulations. Taken together, this far unique combination of methods in experiment and theory will yield results crucial for existing and future medical diagnostics and DNA-based environmental biosensorics.
 
CiDNA Office
Project Coordination:
TUM
TU München (DE)
Prof. Dr. M.E. Michel-Beyerle
Technical University of Munich
Institute of Physical and Theoretical Chemistry
Lichtenbergstr. 4
D-80546 GARCHING
Tel.: +49 89 289 13350
Home: +49 89 367942
Fax: +49 89 289 13026
michel-beyerle@ch.tum.de


CiDNA Office
Gabriele Dietrich
Technical University of Munich (DE)
Institute of Physical and Theoretical Chemistry
Lichtenbergstr. 4
D-80546 GARCHING

Office Hours:
Monday - Thursday 1pm - 5 pm
Tel: +49 89 289-13396
Fax: +49 89 289 13026
cidna@ch.tum.de



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Sihth Framework Programme 2002 - 2006

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